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In a worst case-scenario, cells are incapable to degrade carcinogens or stress-induced toxic intermediates, thus increasing their susceptibility to undergo further steps toward cancer progression or event other diseases ( ∗ B (Val105) allele is often mentioned within the context of genetic polymorphisms, a GSTP1 variation which is characterized by an A→G sequence transition in codon 105 of exon 5, leading to the exchange of isoleucine by valine, thus decreasing its catalytic activity associated with reduced cell detoxification ability ( IMPORTANCE OF GLUTATHIONE S -TRANSFERASE P1 CLASS IN CANCER DEVELOPMENT Furthermore, the previously mentioned cytosolic GSTP1 isoenzyme consist of one of the best-studied variants of the GST metabolism

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Unlike exogenous GH, they avoid receptor desensitization and negative feedback, preserving the natural circadian rhythm of GH